Progress in Research on Surface Enhanced Raman Biochemical Detection of Microelectronics
December 19 01:05:30, 2022
[ Instrument R&D of Instrumentation Network ] Recently, the research team of Chen Dapeng, a researcher of the Integrated Circuit Pilot Technology R&D Center of the Institute of Microelectronics of the Chinese Academy of Sciences, and the research team of Xiong Jijun, a professor of North University of China, have achieved a phase in the field of surface enhanced Raman (SERS) biochemical detection research. progress. Researchers have proposed a super-hydrophobic high-adhesion substrate based on nano-forest for double enrichment of molecules. The prepared 3D structured gold/silver nano-hybrid structure can well restrict the molecules of the analyte to "hot spots" To achieve effective fusion of molecular enrichment and hybrid structure. The prepared SERS substrate can realize the detection of ultra-low concentration molecules, and has specific detection ability for mixed pesticides. The development of this substrate provides new ideas for multi-component detection.
Using the nano forest developed by the research group, the gold nano particles are used as a mask for secondary etching to form a 3D "gold nano cage" on the top of the nano forest, and then the 3D gold/silver nano hybrid structure is formed by sputtering the silver particles. The coupling of different local surface plasmon resonance (LSPR) modes of the bimetallic structure makes it have multiple hybrid characteristics of plasmon. Due to the multiple coupling of plasma and other optical resonance modes caused by nano-hybridization and complex nano-structures, it can realize the efficient enhancement of electromagnetic fields, combined with the secondary enrichment of molecules formed by super-hydrophobic high adhesion, the molecules can be concentrated in Effective "hot spots" can also further improve molecular detection capabilities. For malachite green and fumeishuang, low limit detection of 10-15M and 10-11M can be achieved respectively, and it has application potential for food safety detection.
Related research results are published on Sensors and Actuators B: Chemical with the title of Parahydrophobic 3D nanohybrid substrates with two pathways of molecular enrichment and multilevel plasmon hybridization (DOI: 10.1016/j.snb.2020.128357).
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